Mathematical Performance of Reliability Estimation in Step – the Secretion of Glutamate and Dopamine Due to the Stress Effect in Terms of Ketamine

P.Gomathi Sundari

doi:https://doi.org/10.14445/22315373/IJMTT-V24P510

International Journal of Mathematics Trends and Technology

Research Article | Open Access | Download PDF

Volume 24 | Number 1 | Year 2015 | Article Id. IJMTT-V24P510 | DOI : https://doi.org/10.14445/22315373/IJMTT-V24P510

Mathematical Performance of Reliability Estimation in Step – the Secretion of Glutamate and Dopamine Due to the Stress Effect in Terms of Ketamine

P.Gomathi Sundari

Citation :

P.Gomathi Sundari, "Mathematical Performance of Reliability Estimation in Step – the Secretion of Glutamate and Dopamine Due to the Stress Effect in Terms of Ketamine," International Journal of Mathematics Trends and Technology (IJMTT), vol. 24, no. 1, pp. 73-78, 2015. Crossref, https://doi.org/10.14445/22315373/IJMTT-V24P510

Abstract

In this paper, generally experiences various stresses, which either accelerate or decelerate the part’s failure, during its lifetime. However, in conventional reliability analysis, the influence of varying stresses is seldom explicitly included into reliability estimation. Time-varying stress accelerated life testing (ALT) is to study the failure time and failure mode of a part under pre-planned changing stresses. Comparing to the constant stress ALT, time-varying stress ALT is able to further reduce testing time, as well as estimate product lifetime under a similar varying stress operation condition. This is highly desirable given the pressure to shorten a product’s time-to-market. For example, Ketamine (18 mg/kg, s.c.) evoked a significant release of glutamate and DA, although the glutamate response was slower in onset compared with DA. Pretreatment with either systemic (3 mg/kg s.c.), but not DA, release. When applied directly to the mPFC via the dialysis probe, ketamine had no effect on glutamate release but did significantly enhance the release of DA. Local ketamine, on the other hand, does not increase glutamate but does increase DA release. This suggests that ketamine acts outside of the mPFC to enhance glutamate, but within the mPFC to enhance DA release. The origin of the ketamine effect on mPFC glutamate is currently not known.

Keywords

Stress effects, Glutamate, Dopamine, Ketamine, ALT ,SSA ,CDM.

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