International Journal of Mathematics Trends and Technology
Volume 24 | Number 1 | Year 2015 | Article Id. IJMTT-V24P510 | DOI : https://doi.org/10.14445/22315373/IJMTT-V24P510
In this paper, generally experiences various stresses, which either accelerate or decelerate the part’s failure, during its lifetime. However, in conventional reliability analysis, the influence of varying stresses is seldom explicitly included into reliability estimation. Time-varying stress accelerated life testing (ALT) is to study the failure time and failure mode of a part under pre-planned changing stresses. Comparing to the constant stress ALT, time-varying stress ALT is able to further reduce testing time, as well as estimate product lifetime under a similar varying stress operation condition. This is highly desirable given the pressure to shorten a product’s time-to-market. For example, Ketamine (18 mg/kg, s.c.) evoked a significant release of glutamate and DA, although the glutamate response was slower in onset compared with DA. Pretreatment with either systemic (3 mg/kg s.c.), but not DA, release. When applied directly to the mPFC via the dialysis probe, ketamine had no effect on glutamate release but did significantly enhance the release of DA. Local ketamine, on the other hand, does not increase glutamate but does increase DA release. This suggests that ketamine acts outside of the mPFC to enhance glutamate, but within the mPFC to enhance DA release. The origin of the ketamine effect on mPFC glutamate is currently not known.
[1] . Adams BW, Moghaddam B (2001) Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex. Biol Psychiatry 50:750–757.
[2] . Carfagno ML, Hoskins LA, Pinto ME, Yeh JC, Raffa RB (2000) Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: II. Glutamate (ant) agonists. Ann Pharmacotherapy 34:788–797.
[3] . Cartmell J, Monn JA, Schoepp DD (1999) The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats. J Pharmacol Exp Ther 291:161–170.
[4] . E. O. McSorley, J. C. Lu, and C. S. Li, “Performance of parameter estimates in step-stress accelerated life-tests with various sample sizes,” IEEE Transactions on Reliability, vol. 51, pp. 271–277, 2002.
[5] . G. K. Bhattacharyya, Parametric Models and Inference Procedures for Accelerated Life Tests, 1987.
[6] . R. Miller and W. B. Nelson, “Optimum simple step-stress plans for accelerated life testing,” IEEE Transactions on Reliability, vol. R-32, pp. 59–65, 1983.
[7] . W. Nelson, “Accelerated life testing-step-stress models and data analysis,” IEEE Transactions on Reliability, vol. R-29, no. 2, pp. 103–108,1980.
P.Gomathi Sundari, "Mathematical Performance of Reliability Estimation in Step – the Secretion of Glutamate and Dopamine Due to the Stress Effect in Terms of Ketamine," International Journal of Mathematics Trends and Technology (IJMTT), vol. 24, no. 1, pp. 73-78, 2015. Crossref, https://doi.org/10.14445/22315373/IJMTT-V24P510
PDF 
Abstract 
Keywords 
References 
Citation