International Journal of Mathematics Trends and Technology
Volume 70 | Issue 4 | Year 2024 | Article Id. IJMTT-V70I4P101 | DOI : https://doi.org/10.14445/22315373/IJMTT-V70I4P101
| Received | Revised | Accepted | Published |
|---|---|---|---|
| 12 Feb 2024 | 14 Mar 2024 | 02 Apr 2024 | 15 Apr 2024 |
The drug Ivermectin is considered the medicine of choice in combating onchocerciasis. However, treatment needs to
be repeated once annually or biannually within a period of 10-15 years which covers the worm’s adult life cycle. Therefore, a
model was designed to evaluate the impact of failure to complete treatment on the dynamics of onchocerciasis within the whole
number of human inhabitants domiciled in an environment. The backward bifurcation phenomenon, via the model, was induced
by human deaths caused by Onchocerciasis and the bifurcation range was also shown to be affected by the proportion of the
infected population who complete their treatment. Numerical study of the model reveals that the proportion of affected human
individuals who complete their treatment as well as the relative infectiousness of humans who failed to complete their treatment
have significant influence on the movement of onchocerciasis in the whole number of human inhabitants domiciled in an
environment. In particular, it was seen that an increase in the percentage of individuals who did not complete their structured
medical care has significant impact on the backward bifurcation range. It was also shown that while increasing the treatment
rate of infectious humans is important, control strategies that would encourage people to stay through the treatment period
should also be implemented alongside failure to do this will undermine the gains of improved treatment rates.
Neglected Tropical Diseases, Onchocerciasis, Failed Treatment, Bifurcation, Quantifying, Transmission dynamics.
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Owin Olowu, Ann Nwankwo, Ignatius Ako, "Analytical Investigation of the Impact of Failed Treatments on the Transmission Dynamics of Onchocerciasis," International Journal of Mathematics Trends and Technology (IJMTT), vol. 70, no. 4, pp. 1-18, 2024. Crossref, https://doi.org/10.14445/22315373/IJMTT-V70I4P101
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